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List of Reportable Diseases and REGULATIONS PRESCRIBING CERTAIN DISEASES AS REPORTABLE DISEASES

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What is Mycobacterium avium Paratuberculosis

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La Presse,  April 8, 2001,  Never in My Milk? by Marie France Coutu

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CTV News Report, September  4th, 2001, Researchers Link Cow's Milk to Crohn's Disease

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Does Mycobacterium Paratuberculosis cause Crohn's disease by Alan Kennedy  

(PARA) PARATUBERCULOSIS AWARENESS & RESEARCH ASS.,INC

International Ass. for Paratuberculosis Copyright © 1999-2001

Crohn's Disease Info Center by Dr. Ira Shafran

The Johne's Information Center

History of Early Research on Crohn's disease

Regional Ileitis by Dr. B. Crohn

Got Milk? by Michael Greger, MD Updated January 2001

THE CROHN'S CONNECTION  by Lisa Chamberlain

Dire Warnings About Johne’s
Disease A wake-up call for the dairy industry? January 1998, University of Wisconsin, School of Veterinary Medicine

Dr. Chiodini's Tables

American and European Links

University of Wisconsin School of Veterinary Medicine

Crohn's Family Support Group

ACTION RESEARCH

Canadian Animal CAHNet Health Network

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FOOD STANDARDS ASSOCIATION

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NACC

FOOD STANDARDS ASSOCIATION: Control of MAP (Mycobacterium avium subsp. paratuberculosis) in milk. JANUARY 1, 2006. FOOD HYGIENE LEGISLATION CHANGES.

GUT, July 2005: High prevalence of Mycobacterium avium subspecies paratuberculosis IS900 DNA in gut tissues from individuals with Crohn's disease.

Lancet, September 2004: Culture of Mycobacterium avium subspecies paratuberculosis from the blood of patients with Crohn's disease

JOURNAL OF DAIRY SCIENCE: .................J. Dairy Sci. 85:3198-3205 © American Dairy Science Association, 2002. Effect of Pasteurization on Survival of Mycobacterium paratuberculosis in Milk ................................................A. Gao*, L. Mutharia, S. Chen*, K. Rahn and J. Odumeru* * Laboratory Services Division, University of Guelph, Guelph, Ontario N1H 8J7, Canada Department of Microbiology, University of Guelph, Guelph, Ontario, N1G 2W1, Canada Health Canada, Laboratory for Foodborne Zoonoses, Guelph, Ontario N1G 3W4, Canada

ACTION MEDICAL RESEARCH:..................Good progress towards Crohn’s disease vaccine March 2004. Action Medical Research is calling on the Government to make Crohn’s disease reportable to the health authorities so that we can get a true picture of the extent of this condition.

Culture of Mycobacterium avium suspecies paratuberculosis from the blood of patients with Crohn's, Saleh A Naser, George Ghobrial, Claudia Romero, John F Valentine, Lancet 2004

Molecular Typing of Mycobacterial Isolates Cultured From The Tissue Of Inflammatory Bowel Disease (Crohn's Disease) Patients by Leanne Adams, B.S. Grove City College, Spring Term 2004

PARATUBERCULOSIS AWARENESS AND PAGE 1 RESEARCH ASSOCIATION, INC. PRESS RELEASE FOR IMMEDIATE RELEASE New milk research finds infectious bacteria survives pasteurization MONDAY, AUGUST 9, 2004, PHOENIX, ARIZONA:.....................In a late-breaking session of the International Association for Food Protection, Dr. Jay Ellingson of the Marshfield Clinic Laboratories, Marshfield, WI, USA presented the Clinic s recent findings that the milk we drink is contaminated with an organism that has been implicated as a suspected cause of Crohn s disease Mycobacterium avium subspecies Paratuberculosis (MAP).............CONTACT: Karen Meyer Cheryl Miller PARA, Inc. (Paratuberculosis Awareness and Research Association) Tel: 813-989-9539 Fax: 813- 987-9559 Email: karen@crohns.org cheryl@crohns.org Website: www.crohns.org

CHRONIC CROHN'S CAMPAIGNE: On The 25TH May 2004 Prof John Hermon Taylor gives a presentation to the huge ASM - American Society of Microbiology Symposium in New Orleans, "It Is the Speech Of His Life" he says.

FOOD SAFETY NETWORK: PASTEURIZATION MAY NOT BE THE SEAL OF MILK PURITY WE THINK IT IS, BRITISHSTUDY SUGGESTS. The milk industry has, according to this brief, spent millions of dollars creating the image of a healthy, wholesome beverage for young and old. But how safe really is that pasteurized glass of milk? 01.may.05

International Association for Paratuberculosis: For other possible spread of M. paratuberculosis, vegetables were cultivated (lettuce, radish, tomato) four weeks on soil artificially infected by suspension of M. paratuberculosis of RFLP type B-C1 usually isolated from ruminants and the environment. Identical strains of RFLP types were isolated from the root, stem, leaf, radish and tomato.

The Saturday Evening Post:Unraveling the Mystery of Crohn's Disease Could bacteria found in dairy products play a key role in Crohn's disease? by Patrick Perry March/April 2004

JOHNE'S DISEASE ADDED TO AMENDED HEALTH OF ANIMALS REGULATIONS ''ANNUALLY NOTIFIABLE LIST'' !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

Regulations Amending the Health of Animals Regulations

The purpose of the Health of Animals Act (the Act) is to prevent the introduction of animal diseases into Canada and prevent the spread within Canada of diseases of animals that either affect human health or could have a significant economic effect on the Canadian livestock industry, and to provide for the humane treatment of animals during transport

This proposed amendment to the Health of Animals Regulations will create two distinct lists, an "immediately notifiable list" and an "annually notifiable list", to name diseases of which the CFIA should be made aware for public health and trade purposes. These two notifiable disease lists will include the diseases for which no program exists and for which information is being gathered primarily to meet Canada's international obligation for surveillance of disease in livestock and other animals and for public health purposes. Johne's disease has been added to the ''annually notifiable list.

Worldnet Daily Exclusive Commentary:Crohn's disease, sick cows and contaminated milk: Posted: October 1, 2004 1:00 a.m. Eastern By Chris Bennett © 2004 WorldNetDaily.com Over 20 years of independent research links a common disease in humans characterized by chronic diarrhea and severe abdominal pain with sick cows and contaminated milk. We're not describing a disease process on another continent, or another era. I'm sad to say that we're talking about the United States in 2004

Study Links Animal Bacteria to Crohn's Disease: Reuters Health by Patricia Reaney, September 17, 2004: Dr Saleh Naser and researchers at the University of Central Florida in Orlando believe it is due to a bacterium called Mycobacterium paratuberculosis (MAP) that is found in cattle, sheep and goats suffering from an illness called Johne's disease. "We discovered the bacteria in the blood of Crohn's patients. This is the first time anyone has done that," Naser said in an interview. "There is strong evidence that this bacteria may be responsible for Crohn's disease

CENTER FOR DIGESTIVE DISEASES: Is Crohn's On the Map Yet? Thomas Borody, Centre for Digestive Diseases, Sydney Australia 2046 Acrobat Reader necessary

Novel appearance of healing mucosa following anti-Mycobacterium avium paratuberculosis therapy for Crohn's disease TJ Borody*, SM Leis+, J Chongnan+, R Surace*, K Herdman*, P Recabarren*, and O Ashman*. *Centre for Digestive Diseases (CDD) and +Probiotic Therapy Research Centre (PTRC), Sydney 2046 Australia

THE LANCET: Infectious Diseases Volume 4, Issue 3, March 4, 2004: Crohn's disease, mycobacteria, and NOD2 Marcel A Behr , Makeda Semret , Audrey Poon , and Erwin Schurr : In a recent Personal view paper, Robert J Greenstein presented the rationale behind efforts to elucidate a mycobacterial cause for Crohn's disease.1 Since the scientific case for such an association derives mostly from publications on mycobacteria, it is interesting that Greenstein also introduced the issue of host genetics, most notably as it pertains to susceptibility to mycobacterial diseases. We have been reading the same publications from a combined host-pathogen perspective and wondered about the impact of new developments in Crohn's genetics and innate immunity, with specific reference to whether they contribute to or contradict the role of mycobacteria in Crohn's disease. These considerations have stimulated preliminary investigations; the following case report suggests a unified approach to exploring Crohn's disease pathogenesis, Affiliations: McGill University Health Centre, Montreal, Canada

Incidence of Mycobacterium paratuberculosis in Bulk Raw and Commercially Pasteurized Cows' Milk from Approved Dairy Processing Establishments in the United Kingdom Applied and Environmental Biology May 2002

CTV NEWS UPDATE: Re September 3rd and 4th, 2001, article below. Researchers claim to have found a link between bacteria in cow's milk and Crohn's disease. But it appears Ottawa is doing little to ensure milk safety. http://www.ctv.ca/servlet/ArticleNews/story/CTVNews/20010905/ctvnews805888/

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The New DNA Crohns Vaccine Summary 2006................Professor John Hermon-Taylor Department of Surgery St George’s, University of London London SW17.0RE, UK. Tel: 020 8767 7631 Fax: 020 8725 5582 Email : jhermon@sgul.ac.uk

April 2006...............................................................................................................................We began work on the anti-MAP vaccine in 2001. We knew that the disease-causing properties of MAP lay in only 5% of its DNA genome. So we used modern bioinformatics and computer programs to focus on this 5% and pick 4 key bits of the MAP bug. Two of these bits sit on the MAP surface and two are released from the bug, so all 4 are ‘seen’ by the immune system of someone with Crohn’s disease. MAP DNA speaks a slightly different ‘language’ to human DNA. So over 2002-2003 we synthesised our 4 MAP genes in human DNA-speak and strung them together in a single cassette. In 2003-2004 we inserted this MAP-cassette into 2 harmless carrier viruses called MVA and Ad5 already approved for clinical trial use in TB, malaria and in some cancer vaccines. We showed that the MAP-cassette inserts in MVA and Ad5 were stable and worked nicely. Vaccination of mice with Ad5 to prime and MVA to boost produced huge numbers of anti-MAP hunter-killer cells. There were no side effects and all the mice remained quite healthy. In 2004 - 2005 we tested the vaccination procedure in mice infected with a laboratory strain of MAP. Six months after infection with MAP, sham vaccinated mice had 100-10,000 MAP bugs per gram in their spleens. In the mice which got the real vaccine we could not detect the MAP bug at all in ¾ of them and the bugs were at the lowest limit of detection by a very sensitive DNA test in the others. Mice which had been vaccinated before exposure to MAP infection were also partially protected. Again, none of the mice showed side effects from the vaccine. We have since repeated these studies against a virulent recent disease isolate of MAP and the successful results were confirmed. The modern anti-MAP vaccine we have produced is highly effective in treating MAP infection and offers protection against re-infection. Although further laboratory work is currently in progress we are now in a position to begin the rigorous application process for regulatory and ethical approvals for clinical trials in people. The first step is to get the vaccine made under contract according to Good Manufacturing Practice (GMP) and put through rigorous toxicity testing. The total cost of getting the vaccine into human clinical trials is UK £700,000. We need your help….can you please help? Please make cheques payable to "St George’s University of London" with RLB0057 written on the back, and mailed direct to Prof. Hermon-Taylor (contact details above). Or for credit card donation access the paypal account at http://www.paypal.co.uk with jhermon@sgul.ac.uk . All funds go only for the vaccine. Gift Aid Certificates available. All the scientific indicators so far say that the vaccine treatment will work. If this is borne out in the human clinical trials we shall at last have a totally new and potentially lasting treatment to offer people with Crohn’s disease. Issued by : Prof John Hermon - Taylor to Tim Page - @ The Chronic Crohns Campaign UK : tel no : 01892 783313. Email : tccc.uk@btinternet.com

HealingWell.com Crohn's Disease Resource Center

Description: Features medical news, health articles, doctor-produced video webcasts, message boards and chat rooms, email, newsletters, books and reviews, and resource directories on Crohn's Disease

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BBC NEWS, UK edition, April 28, 2004: Farm guidance on Crohn's welcomed Guidelines to farmers is due to be published next month : A man who nearly lost his wife to Crohn's disease is hoping to influence government guidance to farmers. Tim Paige, of Wadhurst, East Sussex, set up Chronic Crohn's Campaign UK eight years ago after Sarah, his wife became ill. After writing to Tony Blair, he took part in research looking at a possible link between Johne's disease, found in dairy herds, and Crohn's disease.

Incidence of Mycobacterium paratuberculosis in Bulk Raw and Commercially Pasteurized Cows' Milk from Approved Dairy Processing Establishments in the United Kingdom Applied and Environmental Biology May 2002

CTV NEWS UPDATE: Re September 3rd and 4th, 2001, article below. Researchers claim to have found a link between bacteria in cow's milk and Crohn's disease. But it appears Ottawa is doing little to ensure milk safety.http://www.ctv.ca/servlet/ArticleNews/story/CTVNews/20010905/ctvnews805888/

UK NEWS Monday April 22 1996, This older article indicates MAP can also be found in our water: Professor highlights risk from bacteria found in milk and tap water By Victoria MacDonald, Health Correspondent This report appeared in the last edition of The Sunday Telegraph A PROFESSOR'S claim that an organism in cows' milk is causing a bowel disease in humans raises a frightening spectre. His claim that the organism can also be found in tap water is even more disturbing.

.Farmers' new rules to tackle milk bug James Meikle, health correspondent Thursday April 29, 2004:The Guardian Dairy farmers will have to follow tough new rules designed to control an infectious bug which may be spreading from cows to humans through milk.

ClariNews:Bacteria linked to bowel disorder Wednesday, 06-Aug-2003 2:58PM Hermon-Taylor told the BBC he found Mycobacterium avium paratuberculosis bacteria in 92 percent of patients with the disease but only in 26 percent of patients without the condition

.Medscape from Web MD Posted 09/04/2002 Elvira Richter, Johannes Wessling, Norbert Lügering, Wolfram Domschke, and Sabine Rüsch-Gerdes from Emerging Infectious Diseases. Mycobacterium avium subsp. paratuberculosis Infection in a Patient with HIV, Germany from Emerging Infectious Diseases

BBC NEWS: Bacteria linked to bowel disorder Scientists have identified a type of bacteria they believe may cause Crohn's disease

Voluntary Johne’s control coming The program will in place likely by January, with a testing protocol being created by, Frances Anderson, Ontario Dairy Farmer magazine

A voluntary, nation-wide program to identify and control Johne’s in dairy and beef cattle could be in place as early as January 2003, Gord Coukell told Ontario milk producers at their fall policy conference

NEWS BULLETIN: Thursday, November 21, 2002 Scientists Crack Genome Sequence Of Mycobacterium Paratuberculosis.

La Presse: Never in My Milk, published April 8, 2001 by Marie France Coutu

La Presse: Jamais dans mon lait? (en francais).

Research Received from Doctor John Hermon-Taylor **Please download Adobe Acrobat Reader 5 to read the files below, please go to http://www.adobe.com/products/acrobat/readstep2.html

Effect of Commercial-Scale High-Temperature, Short-Time Pasteurization on the Viability of Mycobacterium paratuberculosis in Naturally Infected Cows’ Milk:APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Feb. 2002, p. 602–607 Vol. 68, No. 2 0099-2240/02/$04.00
0 DOI: 10.1128/AEM.68.2.602–607.2002 Copyright © 2002, American Society for Microbiology. All Rights Reserved.2606/pdf

Identification of Mycobacterium avium subsp. paratuberculosis in Biopsy Specimens from Patients with Crohn’s Disease Identified by In Situ Hybridization. sechi.pdf JOURNAL OF CLINICAL MICROBIOLOGY, 0095-1137/01/$04.00
0 DOI: 10.1128/JCM.39.12.4514–4517.2001 Dec. 2001, p. 4514–4517 Vol. 39, No. 12 Copyright © 2001, American Society for Microbiology. All Rights Reserved. NOTES update

Treatment with drugs active against Mycobacterium avium subspecies paratuberculosis can heal Crohn’s disease: more evidence for a neglected Public Health tragedy J. Hermon-Taylor,DIGEST LIVER DIS 2002;34:9-12 Italcomm .pdf

Crohn's disease caused by Mycobacterium avium subspecies paratuberculosis: a public health tragedy whose resolution is long overdue.J. Med. Microbiol. - Vol. 51 (2002), 3-6 2002 Society for General Microbiology ISSN 0022-2615 EDITORIAL jmedmicro2002.pdf

Incidence of Mycobacterium avium subspecies paratuberculosis in bulk-tank milk samples from different regions in Switzerland electrophoresis of KR products obtained fror different bulk-tank mil samples following the nested IS900 PCR. Lane M 100 by molecular weight ladder (Roche Diagnostics), Lanes 1, and 4 Positive samples with a specific amplification product 298 bp, Lane 3 Negativ sample, +Ko Positive.Swiss.Map.pdf